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A compacted and low-offset low-power CMOS amplifier for biosensor application is presented in this paper. It includes a low offset Op-Amp and a high precision current reference. With a novel continuoustime DC offset rejection scheme, the IC achieves lower offset voltage and lower power consumption compared to previous designs. This configuration rejects large DC offset and drift that exist at the skin-electrode interface without the need of external components. The proposed amplifier has beendoi:10.4236/jbise.2009.27078 fatcat:iv2uwwnegjduxl7hz2bs2tnzjy