Cell migration in complex environments: chemotaxis and topographical obstacles

Alessandro Cucchi, Christèle Etchegaray, Nicolas Meunier, Laurent Navoret, Lamis Sabbagh, Nicolas Vauchelet, Vincent Calvez, Magali Ribot, Clair Poignard, Eva Lochërbach, Céline Grandmont
2020 ESAIM Proceedings and Surveys  
Cell migration is a complex phenomenon that plays an important role in many biological processes. Our aim here is to build and study models of reduced complexity to describe some aspects of cell motility in tissues. Precisely, we study the impact of some biochemical and mechanical cues on the cell dynamics in a 2D framework. For that purpose, we model the cell as an active particle with a velocity solution to a particular Stochastic Differential Equation that describes the intracellular
more » ... tracellular dynamics as well as the presence of some biochemical cues. In the 1D case, an asymptotic analysis puts to light a transition between migration dominated by the cell's internal activity and migration dominated by an external signal. In a second step, we use the contact algorithm introduced in [15,18] to describe the cell dynamics in an environment with obstacles. In the 2D case, we study how a cell submitted to a constant directional force that mimics the action of chemoattractant, behaves in the presence of obstacles. We numerically observe the existence of a velocity value that the cell can not exceed even if the directional force intensity increases. We find that this threshold value depends on the number of obstacles. Our result confirms a result that was already observed in a discrete framework in [3,4].
doi:10.1051/proc/202067012 fatcat:mbgnlknkcja2tnk6vwyuaqkmpa