Plasma Resistin Associated With Myocardium Injury in Patients With Acute Coronary Syndrome

Songyun Chu, Wenhui Ding, Kang Li, Yongzheng Pang, Chaoshu Tang
2008 Circulation Journal  
faculty of medicine, Alexandria university, Rheumatology and internal medicine, Alexandria, Egypt; 2 faculty of medicine, Alexandria university, rheumatology and internal medicine, Alexandria, Egypt; 3 faculty of medicine, Alexandria university, radiodiagnosis, Alexandria, Egypt; 4 faculty of medicine, Alexandria university, chemical and clinical pathology, Alexandria, Egypt; 5 faculty of medicine alexandria university, rheumatology and internal medicine, alexandria, Egypt Background: Although
more » ... ckground: Although SLE management has improved markedly in the last few decades, cardiovascular disease (CVD) is still one of the most important leading cause of death. Subclinical atherosclerosis is increased in patients with SLE and it is not fully explained by traditional cardiovascular risk factors. Evidences suggest that resistin is involved in pathological processes leading to CVD including; inflammation, endothelial dysfunction, thrombosis, angiogenesis and smooth muscle cell dysfunction. Objectives: to determine the relation between serum resistin level and carotid intima-media thickness by doppler technique as a marker of premature or subclinical atherosclerosis in SLE patients. Methods: this is a cross-sectional study, carried on thirty Egyptian SLE patients who fulfilled the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria. All patients had metabolic syndrome were excluded. Twenty healthy individuals, non smokers, matched for age and sex as controls. All patients were subjected to detailed history taking, a complete clinical examination. Laboratory investigations were done included serum resistin and HOMA was calculated, also the SLE disease activity index (SLEDAI 2K) and SLE disease damage index (SLEDDI) were applied and the scores were estimated. The carotid intima media thickness (CIMT) was assessed by carotid doppler ultrasonography. Results: There was no statistically significant difference in serum resistin between SLE patients and healthy individuals (p=0.804). As regards the correlation with disease parameters Serum resistin show statistically significant correlation correlation with hs-CRP (p=0.027), HDL (p<0.001), and ANA titre (p=0.013), but no significant correlation with HOMA, SLEDAI, SLEDDI, CIMT and different clinical activities. There was a statistically significant difference in CIMT between SLE patients and the controls (P= 0.006). Conclusion: Although serum resistin is correlated with two of cardiovascular risk factors (HDL, hs-CRP), it doesn't correlate significantly with CIMT in SLE patients. Resistin is correlated to inflammation more than subclinical atherosclerosis. Moreover, SLE patients have higher CIMT than healthy population so SLE is considered a CVD risk factor.
doi:10.1253/circj.72.1249 pmid:18654008 fatcat:xxlwixguvndpbjulsmvtxrq37i