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Motivation: To illustrate an intuitive and statistically valid method for combining independent sources of evidence that yields a p-value for the complete evidence, and to apply it to the problem of detecting simultaneous matches to multiple patterns in sequence homology searches. Results: In sequence analysis, two or more (approximately) independent measures of the membership of a sequence (or sequence region) in some class are often available. We would like to estimate the likelihood of thedoi:10.1093/bioinformatics/14.1.48 pmid:9520501 fatcat:v5rlhcub2fenfe6c7ctbrxq3ie