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Hemorrhagic shock is known to alter significantly the pharmacokinetics of fentanyl, an opioid that requires delivery to the liver for metabolism. The authors hypothesized that the pharmacokinetics and pharmacodynamics of remifentanil, an esterase metabolized opioid that does not require delivery to a metabolic organ, would be altered less by hemorrhagic shock that those of fentanyl. Methods: Sixteen pigs were assigned randomly to control and shock groups. The shock group was bled using andoi:10.1097/00000542-200102000-00023 pmid:11176098 fatcat:55bctxdhn5hqvovkvatqclbmyy