Synthesis of a 2-Furylpyrazoline Derivative Using Microwave Irradiation

Balapragalathan Jothikrishnan, Suban Shafi
2009 Molbank  
A simple method for the synthesis of pyrazoline derivative containing furan moiety was developed. Thus, 5-(6-bromo-1,3-benzodioxol-5-yl)-3-(2-furyl)-1-(3-methylphenyl)-4,5-dihydro-1H-pyrazole was synthesized using microwave irradiation and it was characterized by NMR, IR, and LCMS. Keywords: (2Z)-3-(6-bromo-1,3-benzodioxol-5-yl)-1-(2-furyl) prop-2-en-1-one; 3tolylhydrazine hydrochloride; microwave Aryl furylpyrazolines exhibit antidepressant and anticonvulsant activities [1] . Pyrazolines can
more » ... . Pyrazolines can be synthesized by the reaction between chalcones (1) and arylhydrazines (2) using catalytic amounts of acetic acid in ethanol as solvent under reflux conditions [2] and acetic acid as a solvent [3] . In some cases bases like K 2 CO 3 [4] and Ba(OH) 2 [5] were employed. We are hereby reporting a simple method for synthesizing an aryl furylpyrazoline by a non-conventional method, using microwave conditions, which does not need any catalyst. The work-up procedure is simple and convenient. OPEN ACCESS
doi:10.3390/m613 fatcat:dxctmuzcwbbrxdneyg43medela