Anahtar kelimeler: Otoimmün, ANA, tiroid, silikat

Sultan Al-Mogairen, Oral Veya, Subkutan Sodyum, Silikat Yüklemesi, Sonras› Otoimmün, Tiroid Hastal›¤›n›n
2009 Türk Jem   unpublished
Thyroid gland is a target organ for the hazards of some drugs and toxins. The objective of this experimental study is to demonstrate whether the subcutaneous or oral sodium silicate will induce autoimmune thyroid disease. In this study, twelve Brown Norway rats were selected from my previous study (Almogairen et al, Lupus 2009 April). At 14th week post sodium silicate or normal saline exposure, the rats were sacrificed and then thyroidectomized. Histopathological studies were done in
more » ... done in autoantibody-positive silicate group of six rats and were compared with the equal number of rats in autoantibody-negative control group. Thyroid gland in the sodium silicate group showed epithelial follicular proliferation in 5/6 (83.33%) compared with 2/6 (33.33%) of the corresponding control saline group, p=0.12, but the absolute difference in the percentage between the two groups was 50%; thyroid gland in the subcutaneous sodium silicate subgroup showed epithelial follicular proliferation in a relatively significant number (p=0.05). When correlating the above results with Serum ANA response of the same rats, it might be concluded that sodium silicate may play a role in inducing autoimmune thyroid disease in an immunosensitive rats. Turk Jem 2009; 13: 67-70 Özet Tiroid bezi baz› ilaç ve toksinler için hedef organd›r. Bu deneysel çal›flman›n amac› subkutan veya oral sodyum silikat›n otoimmün tiroid hastal›¤›n› bafllat›p bafllatmayaca¤›n› araflt›rmakt›r. Bu çal›flma için, daha önceki çal›flmamdan (Almoga›ren et al., Lupus 2009 Nisan) 12 Norveç s›çan› seçil-di. Sodyum silikat verilen ve normal sodyum klorür verilen s›çanlar 14 üncü haftada öldürüldü ve tiroidektomi yap›ld›. Otoantikor pozitif olan silikat verilmifl gruptaki alt› s›çan üzerinde histopatolojik incelemeler yap›ld› ve otoantikor negatif olan kontrol grubundaki ayn› say›daki s›çan-larla karfl›laflt›r›ld›. Sodyum silikat grubundaki s›çanlar›n 5/6 s›n›n tiroid bezinde (%83,33) epitelyal follikuler proliferasyon izlenirken bu oran kontrol sodyum klorür grubunda 2/6 (%33,33) idi (p=0,12). Ancak iki grup aras›ndaki kesin fark, oran olarak %50 idi; subkutan sodyum silikat alt grubunda, tiroid bezinde epitelyal follikuler proliferasyon görülen s›çanlar›n say›s› di¤erlerine göre oldukça fazla idi (p=0,05). Yukar›daki sonuçlar, ayn› s›çanlar›n serum antinükleer antikor (ANA) cevab› ile iliflkilendirildi¤inde, sodyum silikat›n immünosensitif s›çanlarda otoimmün tiroid hastal›¤›n›n indüklenmesinde önemli rol oynayabilece¤i sonucuna var›labilir.
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