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Effect of Nebivolol on the Isolated Rat Bladder Strips Precontracted with Carbachol or Potassium Chloride
Clinical and Experimental Health Sciences
Objective: One of the proposed mechanism mediating the vasorelaxant effect of nebivolol is based on its agonistic activity on beta-2 and/or beta-3 adrenergic receptors. These receptors are also involved in the relaxation of urinary bladder. The aim of this study was to explore the ability of nebivolol to induce relaxation of the isolated rat bladder strip precontracted with cholinergic stimuli using carbachol or non-cholinergic stimuli using potassium chloride (KCl). Methods: The isolateddoi:10.33808/clinexphealthsci.731484 fatcat:yvpskzlvtvfnngd4gouhvlnvpi