Innovations in phenotyping of mouse models in the German Mouse Clinic

Helmut Fuchs, Valérie Gailus-Durner, Susanne Neschen, Thure Adler, Luciana Caminha Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker, Alexander Bohla, Julia Calzada-Wack, Christian Cohrs, Anna Dewert, Barbara Fridrich (+59 others)
2012 Mammalian Genome  
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The
more » ... C is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ("bottom-up projects") and as a partner and driver in international large-scale biology projects ("topdown projects"). Furthermore, technology development is H. Fuchs and V. Gailus-Durner contributed equally to this work. H.
doi:10.1007/s00335-012-9415-1 pmid:22926221 pmcid:PMC3463795 fatcat:y6b52bfgprb3rmymu5qeogn62y