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Possible involvement of 4-hydroxy-2-nonenal in the pathogenesis of leptin resistance in obesity
2019
American Journal of Physiology - Cell Physiology
Insensitivity to the antiobesity hormone, leptin, has been suggested to be involved in the pathogenesis of obesity. However, the pathological mechanisms underlying the development of leptin resistance are not well-understood. This study aimed to examine the pathological mechanisms of leptin resistance in obesity. In the present study, we found that 4-hydroxy-2-nonenal (4-HNE), an aldehyde, may be involved in the development of leptin resistance. The SH-SY5Y-Ob-Rb human neuroblastoma cell line,
doi:10.1152/ajpcell.00080.2018
pmid:30789753
fatcat:hn4rv674nbakba6dll6d22mjhi