Association of hematology profile with serum 25-hydroxy vitamin D and Bsml polimorphism in community-dwelling older adults

Alexandre Sérgio SILVA, Chahira Taha Mahd Ibrahim ISSA, Dayanna Joyce Marques QUEIROZ, Darlene Carmati PERSUHN, Eduarda Pontes dos Santos ARAÚJO, Maria da Conceição Rodrigues GONÇALVES
2016 Revista de Nutrição  
Objective: To investigate the association between serum level of 25-hydroxy vitamin D and the Vitamin D Receptos gene BsmI polymorphism in the blood profile of community-dwelling older adults. Methods: This cross-sectional study included 142 older males and females. A questionnaire collected socio demographic information, medical history, and factors associated with sun exposure. Weight, height, and waist circumference were measured. Biological material was collected to analyze biochemical
more » ... ze biochemical parameters 25-hydroxy vitamin D, parathormone, serum calcium, urea, creatinine, liver enzymes, and blood profile) and to verify the presence of the vitamin D receptos gene BsmI polymorphism. Results: Most participants were female (80.3%). The mean levels of 25-hydroxy vitamin D, hemoglobin, and hematocrit were 32.1±7.3 ng/dL, 13.5±1.5 d/dL, and 40.0±4.4%, respectively. Fifty-eight (40.8%) participants had vitamin D insufficiency/deficiency (25.7±3.3 ng/mL), and 18 (12.6%) had anemia. Serum vitamin D was associated with hemoglobin (p=0.030) and hematocrit (p=0.032). However, when subjects were categorized as anemic or not anemic, said association was not maintained (p=0.270). Moreover, the BsmI polymorphism was not associated with hemoglobin and hematocrit levels, regardless of vitamin D status. Conclusion: The serum level of vitamin D is associated with hematocrit and hemoglobin levels in older adults. However, these blood parameters were not associated with the vitamin D receptor gene BsmI polymorphism.
doi:10.1590/1678-98652016000500004 fatcat:ja5fjncd6zhyfpclcndnf2a3sy