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Hydrogen bond synthon competition in the stabilization of theophylline cocrystals
2014
CrysteEngComm
Preserved Fulltext
In the preparation of theophylline cocrystals, phenol coformers facilitate water assimilation due to their weaker O–H⋯N(imidazole) synthon. The presence of –COOH prevents water incorporation and provides added physical stability at high humidity. This study shows the feasibility of cocrystal design of an API to tune physical properties based on hydrogen bond synthons.
doi:10.1039/c3ce42332h
fatcat:gpvbcyawd5dxddin7ypuhivwdq