Conditioned increase of locomotor activity induced by haloperidol [article]

Luis Gonzalo De la Casa, Lucia Carcel, Juan Carlos Ruiz-Salas, Lucia Vicente, Auxiliadora Mena
2018 biorxiv/medrxiv   pre-print
Dopamine antagonist drugs have profound effects on locomotor activity. In particular, the administration of the D2 antagonist haloperidol produces a state that is similar to catalepsy. In order to confirm whether the modulation of the dopaminergic activity produced by haloperidol can act as an unconditioned stimulus, we carried out two experiments in which the administration of haloperidol was repeatedly paired with the presence of distinctive contextual cues that served as a Conditioned
more » ... s. Paradoxically, the results revealed a dose-dependent increase in locomotor activity following conditioning with dopamine antagonist (Experiments 1) that was susceptible of extinction when the conditioned stimulus was presented repeatedly by itself after conditioning (Experiment 2). These data are interpreted from an associative perspective, considering them as a result of a classical conditioning process.
doi:10.1101/353912 fatcat:qbtwzjukc5gzhdgxsbxpauzuee