Nuclear SET domain–containing protein 2 (NSD2; MMSET; WHSC1)

2013 Science-Business eXchange  
Multiple myeloma (MM) Nuclear SET domaincontaining protein 2 (NSD2; MMSET; WHSC1) Mouse and cell culture studies suggest inhibiting NSD2 activity could help treat t(4;14)translocated MM. t(4;14) translocations are found in about 10%-20% of MM cases and drive overexpression of NSD2 and fibroblast growth factor receptor 3 (FGFR3; CD333). In MM cell lines with the t(4;14) translocation, small hairpin RNA knockdown of NSD2 decreased proliferation on and adherence to bone marrow stroma compared with
more » ... no knockdown. In mice injected with MM cells that had doxycyclineinducible NSD2 knockdown, doxycycline decreased tumorigenesis and disease progression compared with no treatment. Next steps could include developing inhibitors of NSD2.
doi:10.1038/scibx.2013.1090 fatcat:2wnygxjkzzhxffyivaoq5dajuq