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Nuclear SET domain–containing protein 2 (NSD2; MMSET; WHSC1)
2013
Science-Business eXchange
Multiple myeloma (MM) Nuclear SET domaincontaining protein 2 (NSD2; MMSET; WHSC1) Mouse and cell culture studies suggest inhibiting NSD2 activity could help treat t(4;14)translocated MM. t(4;14) translocations are found in about 10%-20% of MM cases and drive overexpression of NSD2 and fibroblast growth factor receptor 3 (FGFR3; CD333). In MM cell lines with the t(4;14) translocation, small hairpin RNA knockdown of NSD2 decreased proliferation on and adherence to bone marrow stroma compared with
doi:10.1038/scibx.2013.1090
fatcat:2wnygxjkzzhxffyivaoq5dajuq