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MALDI imaging mass-spectrometry (MALDI-MSI) is a highly informative approach combining morphology with molecular data. It is widely applied in neuroscience, plant science, cancer-biology, biomedicine, including clinical, and preclinical studies, but not for investigation of endogenous peptides/proteins or metabolites in marine invertebrates. We examined the informativeness of MALDIMSI for analysis of distribution of antimicrobial peptides (arenicins) in the polychete Arenicola marina anddoi:10.25431/1824-307x/isj.v13i1.205-209 fatcat:3lj6hhrivzdezcma4ymxs6kl3a