JAK1 (Janus kinase 1)

L Knoops, T Hornakova, JC Renauld
2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Identity Other names: EC 2.7.10.2; JAK-1; JAK1A; JAK1B; JTK3 HGNC (Hugo): JAK1 Location: 1p31.3 DNA/RNA Description 25 exons spanning roughly 135 kb of genomic DNA. Transcription 5053 bp pre-mRNA; 1 transcript described. Protein Description 1154 amino acids; 133,3 kDa; JAK1 contains a Nterminal FERM domain, responsible of the binding to the receptor, a central Src homology 2 (SH2) domain, and two C-terminal domains: a tyrosine kinase domain JH1 and a pseudokinase domain JH2. Expression
more » ... Expression Ubiquitous. Localisation Intracellular, associated to cytokine receptors.
doi:10.4267/2042/44815 fatcat:fk6jwnpycjfgpfdx5huj2ipjiu