Primary Lung Cancer Associated with Diffuse Granulomatous Lesions in the Pulmonary Parenchyma

Yoshihiko SEGAWA, Nagio TAKIGAWA, Masayuki OKAHARA, Yoshinobu MAEDA, Ichiro TAKATA, Masahumi FUJII, Hiroshi MOGAMI, Koichi MANDAI, Mikio KATAOKA
1996 Internal medicine (Tokyo. 1992)  
A 60-year-old man was admitted to our hospital for productive cough. Chest roentgenography and CT scan disclosed a left hilar tumor invading the mediastinum, with mediastinal lymphadenopathy and diffuse micronodular shadows in both lung fields. A biopsied sample of the tumor revealed squamouscell carcinoma, while noncaseating epithelioid cell granulomas were observed in the samples obtained by transbronchial lung biopsy. The granulomas in the pulmonary parenchymawere determined to be sarcoid
more » ... ctions secondary to lung cancer, since there was no evidence ofsarcoidosis. Combination chemotherapy was effective for the tumor, and the granulomas disappeared after completion of the chemotherapy. These findings suggest the presence of a relationship between sarcoid reactions and lung cancer in this case. (Internal Medicine 35: 728-731, 1996)
doi:10.2169/internalmedicine.35.728 fatcat:ftgugftqmravvobxejhzvy56ja