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Novel technologies allow sequencing of whole genomes and are considered as an emerging approach for the identification of rare disease-associated variants. Recent studies have shown that multiple rare variants can explain a particular proportion of the genetic basis for disease. Following this assumption, we compare five collapsing approaches to test for groupwise association with disease status, using simulated data provided by Genetic Analysis Workshop 17 (GAW17). Variants are collapsed indoi:10.1186/1753-6561-5-s9-s115 pmid:22373249 pmcid:PMC3287839 fatcat:55xndsadbbcaxn35k6etd7atpu