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Pericyte insulin receptors modulate retinal vascular remodeling and endothelial angiopoietin signaling
2021
Endocrinology
Pericytes regulate vascular development, stability and quiescence; their dysfunction contributes to diabetic retinopathy. To explore the role of insulin receptors in pericyte biology, we created pericyte insulin receptor knockout mice (PIRKO) by crossing PDGFR β-Cre mice with insulin receptor (Insr) floxed mice. Their neonatal retinal vasculature exhibited peri-venous hypervascularity with venular dilatation, plus increased angiogenic sprouting in superficial and deep layers. Pericyte coverage
doi:10.1210/endocr/bqab182
pmid:34460911
pmcid:PMC8462386
fatcat:k4ka6coltfdofnd5a6hk4o5dj4