Synthesis of Prodrug Polymer as Ring Opening of PVP

Mohammed Firyal, Ali, Halah Humadi, Luma Mussa
2015 Eng. &Tech.Journal   unpublished
In this work a new drug polymer was prepared from reaction of polyvinylpyrrolidone (PVP) with doxycylin in 10:1 dioxane: dimethelyformad solvent mixture. The prepared drug polymer was formed with 85% conversion percentage. The physical properties were studied and intrinsic viscosity was equal to 0.23 dl/g. The drug polymer was characterized by FT-IR and UV spectroscopy. The swelling % was studied in different non solvents. The elemental analysis and DSC were analyzed. The controlled release
more » ... trolled release rates for drug polymer were studied in different pH values at 37 o C for 4 days. The softening point of the prepared doxycyclin drug polymer was 143.4 o C to 150.3 o C with ΔH=-189.89 J/g. ‫ﺑ‬ ‫ﺑﻮﻟﯿﻤﺮﯾﺔ‬ ‫دواﺋﯿﺔ‬ ‫ﻣﻘﺪﻣﺎت‬ ‫ﺗﺤﻀﯿﺮ‬ ‫ﻔ‬ ‫ﺑﺎﯾﺮوﻟﺪﻧﯿﻮن‬ ‫ﻓﺎﻧﯿﻞ‬ ‫اﻟﺒﻮﻟﻲ‬ ‫ﺣﻠﻘﺔ‬ ‫ﺘﺢ‬ ‫اﻟﺨﻼﺻﺔ‬ ‫اﻟﺒﺤﺚ‬ ‫ھﺬا‬ ‫ﻓﻲ‬ ‫ﺣﻀﺮ‬ ‫ﻣﺬﯾﺐ‬ ‫ﻓﻲ‬ ‫اﻟﺪوﻛﺴﯿﺴﺎﯾﻠﯿﻦ‬ ‫ﻋﻘﺎر‬ ‫ﻣﻊ‬ ‫ﺑﺎﯾﺮوﻟﯿﺪﯾﻨﻮن‬ ‫ﻓﺎﯾﻨﯿﻞ‬ ‫اﻟﺒﻮﻟﻲ‬ ‫ﺗﻔﺎﻋﻞ‬ ‫ﻣﻦ‬ ‫دواﺋﻲ‬ ‫ﺑﻮﻟﯿﻤﺮ‬ ‫ﺑﻨﺴﺒﺔ‬ ‫ﻓﻮرﻣﺎﯾﺪ‬ ‫ﻣﺜﯿﻞ‬ ‫واﻟﺪاي‬ ‫اﻟﺪاﯾﻮﻛﺴﺎن‬ 10:1 ‫ﺑﻨﺴﺒﺔ‬ ‫اﻟﺘﺤﻮﯾﺮ‬ ‫ﻧﺎﺗﺞ‬ ‫ﻓﻜﺎن‬ 85% ‫اﻟﻔﯿﺰﯾﺎﺋﯿﺔ‬ ‫اﻟﺼﻔﺎت‬ ‫درﺳﺖ‬ ‫ﺗﺴﺎوي‬ ‫واﻟﺘﻲ‬ ‫ﻟﻠﺒﻮﻟﯿﻤﺮ‬ ‫اﻟﺠﻮھﺮﯾﺔ‬ ‫واﻟﻠﺰوﺟﺔ‬ (0.23dl/g) ‫ﺑﻮاﺳ‬ ‫اﻟﻨﺎﺗﺞ‬ ‫اﻟﺪواﺋﻲ‬ ‫اﻟﺒﻮﻟﯿﻤﺮ‬ ‫وﺷﺨﺺ‬ ‫ﺗﺤﺖ‬ ‫اﻷﺷﻌﺔ‬ ‫ﻄﺔ‬ ‫ﻟﻠﻌﻨﺎﺻﺮ‬ ‫اﻟﺪﻗﯿﻖ‬ ‫اﻟﺘﺤﻠﯿﻞ‬ ‫وأﺟﺮي‬ .‫اﻟﻼﻣﺬﯾﺒﺎت‬ ‫ﻓﻲ‬ ‫اﻟﻤﺌﻮﯾﺔ‬ ‫اﻻﻧﺘﻔﺎخ‬ ‫ﻧﺴﺒﺔ‬ ‫وﻗﯿﺴﺖ‬ ،‫اﻟﺒﻨﻔﺴﺠﯿﺔ‬ ‫ﻓﻮق‬ ‫واﻷﺷﻌﺔ‬ ‫اﻟﺤﻤﺮاء‬ ‫اﻟﺤﺮاري‬ ‫اﻟﺘﺤﻠﯿﻞ‬ ‫إﺟﺮاء‬ ‫وﺗﻢ‬ DSC. ‫دوال‬ ‫ﻓﻲ‬ ‫اﻟﻤﺤﻀﺮ‬ ‫اﻟﺒﻮﻟﯿﻤﺮ‬ ‫ﻣﻦ‬ ‫اﻟﺪواﺋﻲ‬ ‫اﻟﺘﺤﺮر‬ ‫ﺳﺮع‬ ‫درﺳﺖ‬ ‫وﻛﺬﻟﻚ‬ ‫ﻋﻨﺪ‬ ‫ﻣﺨﺘﻠﻔﺔ‬ ‫ﺣﺎﻣﻀﯿﺔ‬ 37 ‫ﻟﻤﺪة‬ ‫م‬ 4 ‫ﺳﯿﻮ‬ ‫درﺟﺔ‬ ‫وﻛﺎﻧﺖ‬ .‫أﯾﺎم‬ ‫ا‬ ‫ﻟﺔ‬ ‫ﺗﺴﺎوي‬ ‫ﻟﺒﻮﻟﯿﻤﺮ‬ : 143.4 o C-150.3 o C ‫واﻟﺘﻐﯿﺮ‬ ‫اﻹﻧﺜﺎﻟﯿﺒﻲ‬ ‫ﻓﻲ‬ 189.89) (‫ﻣﯿﻜﺮوﺟﻮل‬ ‫/ﻏﻢ‬ .
fatcat:fdxyo2g5g5d7dg6ejqz437vgwq