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CD4+T Cell-Mediated Antigen-Specific Immunotherapy in a Mouse Model of Cervical Cancer
2005
Cancer Research
A major agenda for tumor immunology is the generation of specific immune responses leading to the destruction of incipient and frank neoplasia. In this report, we show that a novel HPV16 E7 fusion protein can produce objective therapeutic responses against incipient cervical cancer in genetically engineered mice that express in the cervix the HPV16 early region genes implicated as causative agents in human cervical cancer. Although nonresponsive toward the HPV16 E7 oncoprotein in the CD8 + + +
doi:10.1158/0008-5472.can-04-3444
pmid:15753402
fatcat:2uyku2x2vzhqpebsor7knvgzxq