In Vivo Mast Cell Stabilizing Activity of Different Extracts Of Trigonella Foenum-Graecum on the Rat Mesenteric Mast Cells [dataset]

Iosr Journals, G.V.Subba Reddy2 C.Girish1
2015 Figshare  
Mast cell stabilizing activity of different extracts of Trigonella foenum-graecum was evaluated with the help of rat mesenteric mast cells. The study includes the mesenteries which are pretreated with prednisolone, petroleum ether, methanol and aqueous extract of Trigonella foenum-graecum (250mg, 500mg and 750mg) were analyzed for the degranulation of mast cell during the anaphylactic reactions. It was carried out on the mesenteries of rats, which are sensitized with sheep serum and triple
more » ... rum and triple antigen to induce degranulation of mast cells. Treatment with aqueous extract of Trigonella foenum-graecum (500mg) showed beneficial effect on mast degranulation of actively sensitized rats. The effect was comparable with that of standard drug, Prednisolone. Mast cell stabilizing activity of aqueous extract of Trigonella foenum-graecum on the rat mesenteric mast cells may be possibly due to the membrane stabilizing potential.
doi:10.6084/m9.figshare.1348748.v1 fatcat:rgf5rbfspbbidcmsoxe6g2vkne