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The human mouth is one of the main routes of entry into the body for foreign microorganisms. During the usual course of daily living the host may be invaded by microbes possessing various harmful qualities, or the host may acquire breaks in its defenses, or may undergo operative procedures. In these conditions, the microorganisms find themselves in inadequately protected tissues because of break in local barrier. As tissues are injured and microbes increase, a variety of signals in the hostdoi:10.13005/bbra/1561 fatcat:a4httrul7bgdzazcv2mvmbe3lu