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Smad-dependent Cooperative Regulation of Interleukin 2 Receptor α Chain Gene Expression by T Cell Receptor and Transforming Growth Factor-β
2005
Journal of Biological Chemistry
The interleukin 2 receptor ␣ chain (IL-2R␣) is a component of high affinity IL-2 receptors and thus critically regulates T cell growth and other lymphoid functions. Five positive regulatory regions together control lineage-restricted and activation-dependent IL-2R␣ induction in response to antigen and IL-2. We now show that TGF- cooperates with T cell receptor (TCR) signaling to increase IL-2R␣ gene expression. Moreover, we identify a sixth positive regulatory region that regulates IL-2R␣
doi:10.1074/jbc.m505833200
pmid:16087671
fatcat:afqp6eh3u5ad3ayd53hh2uiqri