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The Activities of Bacterial Pathogens In Vivo
The expression of genes coding for determinants of DNA topology in the facultative intracellular pathogen Salmonella typhimurium was studied during adaptation by the bacteria to the intracellular environment of J774A.1 macrophage-like cells. A reporter plasmid was used to monitor changes in DNA supercoiling during intracellular growth. Induction of the dps and spv genes, previously shown to be induced in the macrophage, was detected, as was expression of genes coding for DNA gyrase, integrationdoi:10.1142/9781848161610_0002 fatcat:5dtqg4matvggnh3wbpmnzplw3e