Antibiotic resistance is a severe worldwide health concern caused by inappropriate use of antibiotics. In most cases, pulp inflammations caused by a root canal system infection do not necessitate the administration of systemic antibiotics to assess the prescriptions' attitude of the endodontist and general dentist towards antibiotics during endodontic treatment. Methodology: Between September 2020 and October 2021, a descriptive study was conducted in Saudi Arabia. Depending on a designed

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... onnaire distributed to general dentists, endodontists in Al-Qassim Province. Data was gathered and entered into the "Microsoft Office excel software" (2016) for Windows program, which was then analyzed using the (SPSS) program. Results: 75.3 % of the 792 participants in the study were males, and 24.7 % were girls. 40.2 % of the study's sample was between the ages of 20 and 25, and 31.4 % was between the ages of 26 and 30. Buraydah has 37.4 %, while Al-Rass has 30.3 %. 61.6 % graduated after 2015, while 19.4 % graduated between 2010 and 2015. Amoxicillin dose prescribed for adults with no allergy was reported to be 500 mg by 66.2% of participants. Amoxicillin + clavulanic acid dose prescribed for adults with no allergy was reported 500mg by 66.3%. Conclusion: In conclusion, Saudi endodontists and dentists follow worldwide guidelines when prescription antibiotics. There were, however, instances of unsuitable prescriptions, as in the case of patients who have irreversible pulpitis, necrotic pulps with no systemic involvement, and/or sinus tracts. Antibiotics and their indications in endodontics must be better understood by endodontist and dentists.