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Oncogenic conversion alters the transcriptional properties of ets
1992
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research
The vEts oncoprotein and its progenitor cEts1(p68) belong to a growing family of transcription factors that are related by the conserved ets domain. We show here that the ets domain and adjacent COOH-terminal amino acids are required for DNA binding by cEts1(p68). vEts differs from cEts1(p68) in both the COOH-terminal sequence and an amino acid substitution in the ets domain. The change in the COOH-terminal sequence markedly decreases its affinity for specific DNA, and the ets domain mutation
pmid:1329927
fatcat:tdcdcrnqyzbwdibybfkbkltrpu