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Outlier analysis of functional genomic profiles enriches for oncology targets and enables precision medicine
2016
BMC Genomics
Genome-scale functional genomic screens across large cell line panels provide a rich resource for discovering tumor vulnerabilities that can lead to the next generation of targeted therapies. Their data analysis typically has focused on identifying genes whose knockdown enhances response in various pre-defined genetic contexts, which are limited by biological complexities as well as the incompleteness of our knowledge. We thus introduce a complementary data mining strategy to identify genes
doi:10.1186/s12864-016-2807-y
pmid:27296290
pmcid:PMC4907009
fatcat:ju3bfqgr6rhuzcix3ciniphufa