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Pancreatic islet cell tumors found in rats given alloxan and nicotinamide
1980
Endocrinologia Japonica
Morphological and biochemical studies were performed in pancreatic islet cell tumors found in rats given alloxan (40 mg/kg) and nicotinamide (305 mg/kg). Complete serial sections of the whole pancreas, combined with planimetric analysis, uncovered islet cell tumors in 5 of 7 rats which were killed 10 to 14 months after treatment. Hypoglycemia associated with hyperinsulinemia was found in a rat which developed a tumor which consisted of cells which reacted lightly with aldehyde fuchsin. Another
doi:10.1507/endocrj1954.27.387
pmid:6254753
fatcat:2vko35v3nnahrnazafbwcbseaq