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Previous studies have demonstrated that highly multivalent DNP conjugates of γ-globulins, but not of KLH or BSA, inhibit the production of anti-DNP IgA antibody by the mouse plasmacytoma line, MOPC 315, in vitro. The present experiments were designed to compare the fate of various DNP antigens, trace-labeled with 125I, in MOPC 315 cells. After continuous exposure of MOPC 315 cells to various antigens for up to 20 hr, suppressive DNP-globulin conjugates are extensively internalized by the cellsdoi:10.4049/jimmunol.122.5.1791 fatcat:5wyns2oj2feyvnolreeiccakx4