2. Introduction 3. The tumor microenvironment 3.1. Epithelial-mesenchymal transition in tumor progression 3.2. The microenvironment activates integrin signaling 3.3. E-cadherin-mediated adherens junctions 4. Regulation of E-cadherin gene expression 4.1. p120 ctn stabilizes E-cadherin-mediated adhesion 4.2. IQGAP influences the association of the E-cadherin complex with actin filaments 5. Extracellular matrix proteins reduce the stability of adherens junctions 5.1. Integrins mediate

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... ced E-cadherin complex disassembly 5.2. Activated focal adhesion kinase associates with the E-cadherin complex 5.3. Catenin phosphorylation in the E-cadherin adhesion complex assembly 6. Regulation of adherens junctions by TGF-beta 6.1. Inhibition of E-cadherin gene expression by TGF-beta 7. Future perspective 8. References