Annual Alveolar Bone Loss in Older Adults Taking Oral Bisphosphonate: A Retrospective Cohort Study [post]

2019 unpublished
Although several studies assessed the effect of bisphosphonate (BIS) administration on alveolar bone loss, this relationship has not been fully investigated using longitudinal analysis. The aim of the this article is to predict annual alveolar bone loss in a subpopulation of older adults patients who were taking oral bisphosphonate (BIS), adjusting for systemic diseases and associated risk factors. Methods: This is a retrospective cohort study. We identified all subjects who reported receiving
more » ... reported receiving oral bisphosphonate from 2008-2015 (N=30) using the electronic health records of each patient to identify suitable radiographs for analysis. For the longitudinal data analysis, 26 subjects were eligible for inclusion, having at least two exposures of the complete mouth set or repeated bitewing radiographs at least a one-year interval; they were then matched on age and sex to another 26 patients who did not report receiving bisphosphonate at any point of their life. Results: Mild periodontitis was higher in the BIS group compared to the no BIS group; however, moderate periodontitis was higher in the no BIS group. For those who did not take oral BIS, change over time was not significant after the two-year period. However, the BIS group had experienced
doi:10.21203/rs.2.11574/v4 fatcat:33y7fsb6hfbgjlatggrwxzsgni