The Mode of Action of Silver and Silver Halides Nanoparticles against Saccharomyces cerevisiae Cells

A. A. Kudrinskiy, A. Yu. Ivanov, E. V. Kulakovskaya, A. I. Klimov, P. M. Zherebin, D. V. Khodarev, Anh-Tuan Le, Le Thi Tam, G. V. Lisichkin, Yu. A. Krutyakov
2014 Journal of Nanoparticles  
Silver and silver halides nanoparticles (NPs) (Ag, AgCl, AgBr, and AgI) capped with two different stabilizers (sodium citrate and nonionic surfactant Tween 80) were obtained via sodium borohydride reduction of silver nitrate in an aqueous solution. The effect of the biocidal action of as-prepared synthesized materials against yeast cells Saccharomyces cerevisiae was compared to the effect produced by silver nitrate and studied through the measurement of cell loss and kinetics of K+ efflux from
more » ... of K+ efflux from the cells depending on concentration of silver. The results clearly indicate that the silver ions either remained in the dispersion of silver NPs and silver halides NPs after their synthesis or were generated afterwards by dissolving silver and silver halides particles playing a major part in the cytotoxic activity of NPs against yeast cells. It was also supposed that this activity most likely does not relate to the damage of cell membrane.
doi:10.1155/2014/568635 fatcat:srnghelqk5dmblnm4blojg5you