Aim: To evaluate the antimicrobial efficacy of Curcuma Longa, 17% EDTA, and 3% sodium hypochlorite against E.faecalis, C.Albicans. Materials and Methods: The antimicrobial activity was determined using disc diffusion test. Ethanol extract of turmeric, 3% Sodium hypochlorite, 17% EDTA, absolute ethanol, Enterococcus faecalis cultures, Candida Albican cultures, Mueller Hinton agar. The disc diffusion test was performed in Mueller Hinton agar plates. The plates were incubated at 37°C for 24 hours

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... nd zone of inhibition were recorded. Finally, it was statistically analyzed. Results: Ethanol extract of turmeric showed zones of inhibition suggesting that they had anti-microbial properties. Ethanol extract of turmeric showed significantly greater (almost same) zones of inhibition than 2% chlorhexidine. Henceforth research should be directed towards the use as an irrigant in root canal treatment. Conclusion: Under the limitations of this study, it was concluded that Ethanol extract of turmeric has a significant antimicrobial effect against E. faecalis. Microbial inhibition potential of ethanol extract of turmeric observed in this study opens perspectives for its use as an intra-canal irrigant.