Sleep Terrors in Twins

J Gordon Millichap
2008 Pediatric Neurology Briefs  
The effects of phenobarbital and diazepam on cell proliferation and neurogenesis were studied in newborn rats followed for 6 months, in a . The N-methyl-D-aspartate antagonist MK801, and the GABA subtype A agonists phenobarbital and diazepam administered to infant rats on postnatal days 6-10 caused reduced numbers of neurons in the hippocampal dentate gyrus at postnatal day 15. No apoptosis was demonstrated. At age 6 months, phenobarbital-treated rats had fewer neurons in the dentate gyrus and
more » ... dentate gyrus and performed worse than saline-treated littermates in water maze learning and memory task. Blockade of N-methyl-D-aspartate receptor-mediated excitation and enhancement of GABA subtype A receptor activation impair cell proliferation and inhibit neurogenesis in the immature rat brain. These findings raise concerns about the frequent use of phenobarbital in the treatment of neonatal seizures. (Stefovska VG, Uckermann O, Czuczwar M, et al. Sedative and anticonvulsant drugs suppress postnatal neurogenesis. Ann Neurol Oct 2008;64:434-445).
doi:10.15844/pedneurbriefs-22-12-5 fatcat:d4qkajoveze5nawzy3sz472ytm