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Journal of Virology
Expression of the retroviral vector Neor myeloproliferative sarcoma virus (MPSV), which contains the v-mos oncogene and the neomycin resistance gene, leads to neoplastic transformation of mouse fibroblasts. Murine recombinant gamma interferon (IFN--y) could revert the neoplastic properties of established Neor MPSVtransformed cell lines to an apparently untransformed phenotype. In the presence of IFN-y, the Neor MPSV transformants showed a greater than 97% reduction of cloning efficiency in softdoi:10.1128/jvi.61.8.2567-2572.1987 fatcat:4zpulppjbvfhrn33vy6whv5csu