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The role of T H 17 cells in cancer is being investigated, but the existence of tumor antigen-specific T H 17 cells has yet to be ascertained. Here, we report the first description of a spontaneous T H 17 (IL-17 þ ) response to the important tumor antigen MAGE-A3, which occurred concurrently with a T H 1 (IFN-g þ ) response in a lung cancer patient. MAGE-A3-specific interleukin (IL)-17 þ T cells were mainly CCR7 þ central memory T cells, whereas IFN-g þ cells were enriched for CCR7 À effectordoi:10.1158/0008-5472.can-11-3432 pmid:22253231 fatcat:y64p44aav5gyvcthhcwzeqoxum