A new 5α,8α-epidioxysterol with immunosuppressive activity from the South China Sea soft coral Sinularia sp

Min Yang, Lin-Fu Liang, Heng Li, Wei Tang, Yue-Wei Guo
2019 Figshare  
A new 5α,8α-epidioxysterol, namely yalongsterol A (1), along with two known related steroids 5α,8α-epidioxy-24-methyl-cholesta-6,24(28)-dien-3β-ol (2) and (22E,24S)-5α,8α-epidioxy-24-methyl-cholesta-6,22-dien-3β-ol (3), were isolated from the South China Sea soft coral Sinularia sp. Their structures were established by extensive spectroscopic analyses and comparisons of the spectral data with those reported in the literature. In bioassay, compounds 1–3 showed moderate immunosuppressive
more » ... uppressive activities against T and/or B lymphocyte cells with IC50 values ranging from 19.30 to 59.49 μM, and low cytotoxicity on murine splenocytes with CC50 values ranging from 40.88 to 62.29 μM.
doi:10.6084/m9.figshare.7642457.v1 fatcat:oq5bdh45r5fppilfztpp7o5uaq