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Molecular basis for inhibition of adhesin-mediated bacterial-host interactions through a novel peptide-binding domain
[article]
2020
bioRxiv
pre-print
Modulation of protein-protein interactions (PPIs) with small-molecules is a promising conceptual approach in drug discovery. In the area of bacterial colonization, PPIs contribute to adhesin-mediated biofilm formation that cause most infections. However, the molecular basis underlying these adhesin-ligand interactions is largely unknown. The 1.5-MDa adhesion protein, MpIBP, uses a peptide-binding domain (MpPBD) to help its Antarctic bacterium form symbiotic biofilms on sea ice with microalgae
doi:10.1101/2020.11.18.389114
fatcat:ynwedixd7fdcdc3gr2z4spbpqe