The Correlation Between Deltamethrin Exposure and Urinary 3-PBA Concentrations in Rats
Deltamethrin에 노출된 흰쥐의 뇨 중 3-PBA 검출 및 노출상관성

Areumnuri Kim, Kyongmi Chon, Kyung-Hun Park, Byeong-Chul Moon, Jin-Ho Ro, Min Kyoung Paik
2017 Korean Journal of Environmental Agriculture  
BACKGROUND: Pyrethroids (PYRs) are a widely used insecticide in agriculture and household area. In mammals, PYRs such as deltamethrin is metabolized to 3-phenoxybenzoic acid (3-PBA) in liver that is mainly excreted in urine. This study is designed to single exposure of deltamethrin to rats in a dose-dependent manner and identify the correlation between deltamethrin exposure and its metabolite (3-PBA) in urine. METHODS AND RESULTS:Exposure levels of deltamethrin were control (0 mg/kg bw), low
more » ... 0 mg/kg bw), low (0.0705 mg/kg bw), medium (0.705 mg/kg bw) and high (7.05 mg/kg bw) dose. Low concentration was derived by ussing Korea predictive operator exposure model (KoPOEM). Dermal exposure persisted for 6 h, and urine specimens were collected for 24 h. The urine matrix was removed after a series of procedures and 3-PBA was analyzed by gas chromatography/mass spectrometry. CONCLUSION: There was a strong correlation (R 2 =0.83) between the amount of oral exposure to delta me thrin and urinary levelof3-PBAexcreted. In dermal exposure groups of deltamethrin except high-dose, also there was a good correlation between urinary 3-PBA and deltamethrin exposure, but not stronger than in oral deltamethrin exposure groups. Based on these results, therefore, the amount of 3-PBA in urine can be used as a good monitoring indicator that reflexing the exposure level of deltamethrin to human body.
doi:10.5338/kjea.2017.36.4.41 fatcat:yi5votomhzeo7mlwdjonofacwu