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Early experiments demonstrated genetic restriction in the pattern of infection with L. sigmodontis in various inbred strains of mice (Petit et al., 1992) . BALB/c mice were the most susceptible and this strain has been used for vaccina tion experiments. FATE OF L SIGMODONTIS IN BALB/C MICE ; VACCINATION pwo months after inoculation with normal 25 L3, all mice inoculated harboured adult filariae with a mean of 4.6 worms (range from 1.5 to 10.6 based on 9 experiments with 7 to 15 mice perdoi:10.1051/parasite/199401s1031 fatcat:lpdkkubtpjhktj5arnkomiwvre