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In light of a growing research interest in the innovation potential that lies at the intersection of design, technology, and science, this paper offers a literature review of design initiatives centered on scientific discovery and invention. The focus of this paper is on evidence of design capabilities in the academic research environment. The results are structured along the Four Orders of Design, with examples of design-in-science initiatives ranging from (1) the design of scientific figuresdoi:10.33114/adim.2019.02.275 fatcat:ow6oq2gldfglplad2ovy7urbni