Improvement of bone repair in diabetic rats subjected to ƛ780 nm low-level laser therapy

Marismar Fernandes do Nascimento, Bernadeth Moda de Almeida, John Lennon Silva Cunha, Rafael Barreto Vieira Valois, Juliana Campos Pinheiro, Maria Amália Gonzaga Ribeiro, Sonia Oliveira Lima, Ricardo Luiz Cavalcanti de Albuquerque-Júnior
2015 Acta Cirurgica Brasileira  
Brazil. Design of the study, histological examinations, manuscript writing, supervised all phases of the study. ABSTRACT PURPOSE: To investigate the effect of low-level laser therapy on bone healing in diabetic rats. METHODS: Bone cavities (19 mm diameter) were performed in the femur of 72 alloxan-induced diabetic rats, which were assigned into four groups: CTR (non-diabetic control), DBT (diabetic) CTRL (non-diabetic irradiated) and DBTL (diabetic irradiated). Low-level laser therapy was
more » ... r therapy was performed every 48h for seven days. Animals were euthanized at seven, 18 and 30 days. Alkaline phosphatase serum levels and bone repair were analyzed. RESULTS: Low-level laser therapy significantly increased alkaline phosphatase in at seven and 18 days (p<0.001), and improved bone healing at seven (p<0.01), 18 (p<0.05) and 30 (p<0.01) in diabetic animals. In addition, bone healing in irradiated diabetic group was statistically similar to control group at 30 days (p>0.05). CONCLUSION: Low-level laser therapy increased the serum levels of alkaline phosphatase and improved bone healing in alloxaninduced diabetic rats.
doi:10.1590/s0102-865020150100000002 pmid:26560423 fatcat:323jluud35fddaww62mjcod6n4