Stabilization and harvesting of Hesperetin microrods from the Hesperetin stabilised via Plantacare 2000 solution by using template-assisted particle infiltration method

Yesim Karahan, Marcel Pourasghar, Marc Schneider, Cornelia M. Keck, Dolunay Sakar Dasdan
2020 Zenodo  
Chemistry Department, Faculty of Art and Science, Yildiz Technical University, 34210 Istanbul, Turkey Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbrücken, Germany Pharmaceutical Technology and Biopharmacy, Marburg University, 35037 Marburg, Germany E-mail: Manuscript received online 20 October 2020, revised and accepted 31 October 2020 Recent studies have shown that the particle properties of drugs play a major role
more » ... for drug delivery systems. One of the important factors in pulmonary drug delivery is the particle shape, and studies in the literature show that cylindrical rods have the highest acquisition and binding efficiency. Hesperetin has antioxidant, anti-carcinogenic, anti-hypertensive, anti-atherogenic, anti-inflammatory etc. effects and its solubility in water is very low. Considering all this information Hesperetin microrods for use in pulmonary drug delivery were tried to be obtained from Hesperetin dispersed with Plantacare 2000 by applying template-assisted method with particle infiltration approach which has three steps: infiltration, stabilization and harvest. In this study, microrods inside the pores which are obtained by Hesperetin-Plantacare 2000 solution infiltrating into pores of tracketched polycarbonate membranes, were stabilized by using different polymers and harvested.
doi:10.5281/zenodo.5666403 fatcat:f4g25rb4qneevawmeqnnot2rgu