Object. The goal of this study was to evaluate gene delivery to a benign brain tumor. Methods. A recombinant adenovirus vector bearing the Escherichia coli ß-galactosidase reporter gene was selectively injected into the vascular supply of a spontaneously occurring canine olfactory groove meningioma. The tumor and a small amount of peritumoral brain tissue were removed 5 days after viral injection and stained with X-Gal to assess gene delivery. The authors noted significant ß-galactosidase gene

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... xpression by the tumor, but not by surrounding brain tissue. No obvious viral-related cytotoxicity was noted. Conclusions. The authors found that meningiomas can be successfully transduced by adenovirus vectors by using endovascular techniques.