2′-Fluoro-c-di-GMP as an oral vaccine adjuvant

Jia Li, Rhonda Kuo Lee, Wangxue Chen, Hongbin Yan
2019 RSC Advances  
2′-F-c-di-GMP was synthesized through the modified H-phosphonate chemistry. 2′-F-c-di-GMP was found to be an effective mucosal vaccine adjuvant, both intranasally and orally.
doi:10.1039/c9ra08310c fatcat:64annsjjvjdfnittjaxa3lvvbi