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High Affinity Binding of β2-Glycoprotein I to Human Endothelial Cells Is Mediated by Annexin II
2000
Journal of Biological Chemistry
 2 -Glycoprotein I ( 2 GPI) is an abundant plasma phospholipid-binding protein and an autoantigen in the antiphospholipid antibody syndrome. Binding of  2 GPI to endothelial cells targets them for activation by anti- 2 GPI antibodies, which circulate and are associated with thrombosis in patients with the antiphospholipid antibody syndrome. However, the binding of  2 GPI to endothelial cells has not been characterized and is assumed to result from association of  2 GPI with membrane
doi:10.1074/jbc.275.20.15541
pmid:10809787
fatcat:s6tvyu6wcbgutb77523tnh4tme