Five healthy male dogs were selected in this study to find out the effects of Xylazine hydrochloride (0.2mg/kg) and Ketamine (8mg/kg) anesthetic protocol on pulse rate, respiratory rate and body temperature simultaneously. These parameters were recorded before administration of the drugs and then after 5 minutes of administration, followed by 15 minutes each interval for two hours. The average control values for pulse rate, respiratory rate and body temperature were recorded 83.20+7.29,

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... 42 and 101.6+1.14 respectively. Significant increase in pulse rate (116.40+3.84) and respiratory rate (52.00+6.32) were observed after 5 minutes of anesthetic administration while body temperature remained normal from 0 to 120 minutes. Decrease in pulse rate (106.80+36.3) and respiratory rate (48.00+6.96) were observed beyond 15 minutes, while normal pulse rate (86.40+2.60) and respiratory rate (28.40+2.19) recorded at 105 minutes. In conclusion, Xylazine and Ketamine have significant effects on pulse and respiratory rate. However, body temperature remains normal with use of these drugs.