Silver and Antibiotic, New Facts to an Old Story

Frédéric Barras, Laurent Aussel, Benjamin Ezraty
2018 Antibiotics  
The therapeutic arsenal against bacterial infections is rapidly shrinking, as drug resistance spreads and pharmaceutical industry are struggling to produce new antibiotics. In this review we cover the efficacy of silver as an antibacterial agent. In particular we recall experimental evidences pointing to the multiple targets of silver, including DNA, proteins and small molecules, and we review the arguments for and against the hypothesis that silver acts by enhancing oxidative stress. We also
more » ... e stress. We also review the recent use of silver as an adjuvant for antibiotics. Specifically, we discuss the state of our current understanding on the potentiating action of silver ions on aminoglycoside antibiotics.
doi:10.3390/antibiotics7030079 pmid:30135366 fatcat:jgl7z45wbbhxll6mgezbtkiuxm