Identification of D Modification Sites by Integrating Heterogeneous Features in Saccharomyces cerevisiae

Pengmian Feng, Zhaochun Xu, Hui Yang, Hao Lv, Hui Ding, Li Liu
2019 Molecules  
As an abundant post-transcriptional modification, dihydrouridine (D) has been found in transfer RNA (tRNA) from bacteria, eukaryotes, and archaea. Nonetheless, knowledge of the exact biochemical roles of dihydrouridine in mediating tRNA function is still limited. Accurate identification of the position of D sites is essential for understanding their functions. Therefore, it is desirable to develop novel methods to identify D sites. In this study, an ensemble classifier was proposed for the
more » ... oposed for the detection of D modification sites in the Saccharomyces cerevisiae transcriptome by using heterogeneous features. The jackknife test results demonstrate that the proposed predictor is promising for the identification of D modification sites. It is anticipated that the proposed method can be widely used for identifying D modification sites in tRNA.
doi:10.3390/molecules24030380 fatcat:zpzr4ixi5jgrncifzjaxxonnoe